Appendix VI – Prefrontal Cortex Research Links

brain prefrontal cortex gambling

If you haven’t read the book yet then this post won’t mean much to you. But here is just a small selection of articles and tests regarding PFC interference or shutdown. A search of Google Scholar and other resources suggest there could be in the region of 100+ studies with similar findings, dating back to the mid-nineties. It would appear that the academics have been aware of this for some time.

 

Prefrontal cortex activity is reduced in gambling and non-gambling substance users during decision-making – US National Library of Medicine – 2007 – https://www.ncbi.nlm.nih.gov/pubmed/17274020

Pathological Choice: The Neuroscience of Gambling and Gambling Addiction – US National Library of Medicine – 2013https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858640/

Prefrontal Cortex Activity Reduced in Gambling & Nongambling Substance Users During Decision-Making – 2007http://psych.colorado.edu/~cuchangelab/publications/hutchison/2007/prefrontalcortexgambling.pdf

Gambling Addiction and the Brain – Brain Facts – 2015 – https://www.brainfacts.org/Diseases-and-Disorders/Addiction/2015/Gambling-Addiction-and-the-Brain

Brain Cells in the Avian ‘Prefrontal Cortex’ Code for Features of Slot-Machine-Like Gambling – 2011https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014589

A neurocognitive comparison of cognitive flexibility and response inhibition in gamblers with varying degrees – 2011https://www.cambridge.org/core/journals/psychological-medicine/article/neurocognitive-comparison-of-cognitive-flexibility-and-response-inhibition-in-gamblers-with-varying-degrees-of-clinical-severity/484DFBF908109D93CC3D9B08923AAB06

Impulsivity and response inhibition in alcohol dependence and problem gambling – 2009 – https://link.springer.com/article/10.1007/s00213-009-1645-x

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications – US National Library – 2011https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462342/

Role of Dopamine, the Frontal Cortex and Memory Circuits in Drug Addiction: Insight from Imaging Studies – 2002https://www.sciencedirect.com/science/article/pii/S1074742702940992

Addiction and the Prefrontal Cortex An Interview with Rita Z. Goldstein, Ph.D. – 2007
http://www.dana.org/Publications/ReportDetails.aspx?id=44208

Highway to addiction: how drugs and alcohol can hijack your brain – University of Cambridge – 2016https://www.cam.ac.uk/research/features/highway-to-addiction-how-drugs-and-alcohol-can-hijack-your-brain

Neural circuits responsible for conscious self-control are highly vulnerable to even mild stress. When they shut down, primal impulses go unchecked and mental paralysis sets in – Library of Medicine – 2012 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774859/

Rats consume 3 times as much cocaine when the Amygdala is activated – 2017http://www.jneurosci.org/content/37/35/8330

Reduced insular size in Attention Deficit Hyperactivity Disorder – 2012https://www.sciencedirect.com/science/article/pii/S0925492712002466

Different Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making – 1999http://www.jneurosci.org/content/19/13/5473

Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions – 2000https://academic.oup.com/brain/article/123/11/2189/255844

Frontal lobe dysfunction in pathological gambling patients – 2002https://www.sciencedirect.com/science/article/pii/S0006322301012276

The above is just a selection I picked, but there are far more available.

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