Appendix VI – Prefrontal Cortex Research Links

brain prefrontal cortex gambling

If you haven’t read the book yet then this post won’t mean much to you. But here is just a small selection of articles and tests regarding PFC interference or shutdown. A search of Google Scholar and other resources suggest there could be in the region of 100+ studies with similar findings, dating back to the mid-nineties. It would appear that the academics have been aware of this for some time.


Prefrontal cortex activity is reduced in gambling and non-gambling substance users during decision-making – US National Library of Medicine – 2007 –

Pathological Choice: The Neuroscience of Gambling and Gambling Addiction – US National Library of Medicine – 2013

Prefrontal Cortex Activity Reduced in Gambling & Nongambling Substance Users During Decision-Making – 2007

Gambling Addiction and the Brain – Brain Facts – 2015 –

Brain Cells in the Avian ‘Prefrontal Cortex’ Code for Features of Slot-Machine-Like Gambling – 2011

A neurocognitive comparison of cognitive flexibility and response inhibition in gamblers with varying degrees – 2011

Impulsivity and response inhibition in alcohol dependence and problem gambling – 2009 –

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications – US National Library – 2011

Role of Dopamine, the Frontal Cortex and Memory Circuits in Drug Addiction: Insight from Imaging Studies – 2002

Addiction and the Prefrontal Cortex An Interview with Rita Z. Goldstein, Ph.D. – 2007

Highway to addiction: how drugs and alcohol can hijack your brain – University of Cambridge – 2016

Neural circuits responsible for conscious self-control are highly vulnerable to even mild stress. When they shut down, primal impulses go unchecked and mental paralysis sets in – Library of Medicine – 2012 –

Rats consume 3 times as much cocaine when the Amygdala is activated – 2017

Reduced insular size in Attention Deficit Hyperactivity Disorder – 2012

Different Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making – 1999

Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions – 2000

Frontal lobe dysfunction in pathological gambling patients – 2002

The above is just a selection I picked, but there are far more available.

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